New Technology May Increase Organ Transplants

core-dynamics.gifIsraeli biotech company Core Dynamics has released the results of a study this month that demonstrate the feasibility of recovering a functional heart after it has been frozen and then thawed. Its unique controlled freezing method, which is based on the Company’s patented Multi Thermal Gradient (MTG) freezing technology, reduces the damage to cells caused by uncontrolled freezing techniques.

Founded in 1996 by Dr. Amir Arav, the cryopreservation company is hoping their solution will help address the tremendous shortage of donor organs, a problem which is exacerbated by the difficulty of maintaining organ viability until time of transplant. A human heart, for example, is restricted to just a few hours of harvest, transport and transplant time, which makes donor-recipient matching between remote locations extremely complicated. Due to these time constraints organ matching of all types of organs is limited to blood type and patient size.

freeze.jpgThe ability to prolong the shelf-life of donated organs would improve the quality of donor-recipient matching and increase the likelihood of receiving organs in any part of the world. Common post-transplant complications could also be reduced as a result of better matching.

Prof. Amir Elami from the Hadassah-Hebrew University Medical Center is hopeful: “These results are very encouraging.” “We believe that this achievement will lead to a time when we can bank cryopreserved organs in well-managed organ banks, and have ample time to assure we have the best match for the most critical-need patients.”

The research project was a joint effort between scientists at Core Dynamics and Hadassah-Hebrew University Medical Center in Jerusalem. The process is already being used today in niche applications in Eastern Europe, and the Company expects to begin marketing these uses in the U.S. shortly.

For more info see Core Dynamics’ press release.

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3 Responses

  1. […] change the way organs are frozen and thawed, enhancing their viability until time of transplant. Israel Start-Up News has the details. Share […]

  2. Directional freezing, allows precise control over ice crystal propagation during the freezing process, thereby substantially reducing the mechanical damage caused to cells during freezing. The technology is based on moving the biological material through linear temperature gradients at predetermined velocities. This technology is particularly important in say a human heart, for example, is limited to a few hours of harvest, transport and transplant time, which makes donor-recipient matching difficult.
    Directional freezing may increase the chances of successful heart transplants.
    Raj Nihalani, MD, RAC(US)

  3. […] Startup Arbel Medical in Second Round Posted on April 27, 2008 by Dani Dechter Last month we reported on Core Dynamics, a company that develops technology to freeze human organs and increase their […]

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